Endocrine Abstracts

Introduction: Metformin is a cornerstone in the treatment of type 2 diabetes, but in recent years several studies have shown that metformin use is associated with a 4-24% decrease in vitamin B12 levels. It is estimated that this problem occurs in approximately 10-30% of patients using metformin and may contribute to distal symmetrical polyneuropathy (DSPN), a very common and clinically relevant diabetic complication.Objective: To study vitamin B12 concen...